Bendick C, Rasokat H, Steigleder G K
Universitäts-Hautklinik Köln.
Z Hautkr. 1989 Feb 15;64(2):91-5.
We report on 2 male patients treated with zidovudine (azidothymidine), who developed longitudinally striated coloration of their nails and lentigines. Both patients are suffering from advanced HIV disease with opportunistic infections. Following treatment with zidovudine 1200 mg daily for 3 and 6 months resp., we observed longitudinal streaks of brownish color in both patients; they did not receive any other drugs known to induce discoloration of the nail plate. Our cases possibly reflect antiproliferative effects of zidovudine at the particularly susceptible nail matrix.
我们报告了2例接受齐多夫定（叠氮胸苷）治疗的男性患者，他们出现了指甲纵向条纹状色素沉着和雀斑。两名患者均患有晚期艾滋病并伴有机会性感染。分别接受每日1200毫克齐多夫定治疗3个月和6个月后，我们在两名患者中均观察到褐色纵向条纹；他们未服用任何其他已知可导致甲板变色的药物。我们的病例可能反映了齐多夫定在特别敏感的甲母质处的抗增殖作用。
