造血干细胞移植后白癜风：6例病例及文献复习
Vitiligo after hematopoietic cell transplantation: six cases and review of the literature.
作者信息
Sanli Hatice, Akay Bengu Nisa, Arat Mutlu, Koçyigit Pelin, Akan Hamdi, Beksac Meral, Ilhan Osman
机构信息
Department of Dermatology, Ankara University School of Medicine, Ankara, Turkey.
出版信息
Dermatology. 2008;216(4):349-54. doi: 10.1159/000117705. Epub 2008 Feb 20.
AIM
To investigate the prevalence and clinical characteristics of vitiligo after allogeneic hematopoietic cell transplantation (AHCT).
METHODS
The development of vitiligo was analyzed among 421 patients who underwent AHCT in Ibni Sina Hospital (University of Ankara) between 1988 and 2004.
RESULTS
Among 421 patients, we describe 6 with generalized vitiligo occurring after AHCT for chronic myelogenous leukemia. Five of them had severe chronic graft-versus-host disease (GVHD). Vitiligo was accompanied by alopecia areata and acquired ichthyosis in 2 patients with GVHD.
CONCLUSION
Melanocyte destruction caused by the autoimmune reactions triggered by chronic GVHD as well as a genetic predisposition might have played a role in the development of vitiligo in our patients. These data support the hypothesis that vitiligo is an autoimmune entity.
目的
研究异基因造血细胞移植（AHCT）后白癜风的患病率及临床特征。
方法
分析了1988年至2004年间在伊本·西那医院（安卡拉大学）接受AHCT的421例患者中白癜风的发生情况。
结果
在421例患者中，我们描述了6例在接受AHCT治疗慢性粒细胞白血病后出现泛发性白癜风的患者。其中5例患有严重的慢性移植物抗宿主病（GVHD）。在2例患有GVHD的患者中，白癜风伴有斑秃和获得性鱼鳞病。
结论
慢性GVHD引发的自身免疫反应以及遗传易感性导致的黑素细胞破坏可能在我们患者白癜风的发生中起了作用。这些数据支持白癜风是一种自身免疫性疾病的假说。
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