Lachance D, Garcia R
Clinical Research Institute of Montreal, Quebec, Canada.
Regul Pept. 1991 Mar 26;33(1):31-8. doi: 10.1016/0167-0115(91)90012-6.
The effect of beta-adrenergic stimulation on atrial natriuretic factor (ANF) release was studied in conscious rats. 20-min infusion of 85 or 850 ng kg-1 min-1 isoproterenol (ISO) resulted in positive inotropic and chronotropic responses and no elevation of atrial pressures. A slight increase in plasma ANF, together with a drop in blood pressure, were observed only in the group infused with the higher dose. During the infusion of 850 ng kg-1 min-1 ISO, there was no relationship between plasma ANF and any of the haemodynamic parameters, with the exception of mean arterial pressure (r = 0.72, P less than 0.05, n = 9). Larger doses (greater than 3 micrograms kg-1 min-1) were toxic. We conclude that beta-adrenergic stimulation is not an important stimulus for ANF release when diastolic resting tension is low.
在清醒大鼠中研究了β-肾上腺素能刺激对心房利钠因子（ANF）释放的影响。以85或850 ng kg-1 min-1的异丙肾上腺素（ISO）输注20分钟，导致正性肌力和变时性反应，且心房压力无升高。仅在输注较高剂量的组中观察到血浆ANF略有增加，同时血压下降。在输注850 ng kg-1 min-1 ISO期间，除平均动脉压外，血浆ANF与任何血流动力学参数之间均无关系（r = 0.72，P < 0.05，n = 9）。更大剂量（大于3微克 kg-1 min-1）具有毒性。我们得出结论，当舒张期静息张力较低时，β-肾上腺素能刺激不是ANF释放的重要刺激因素。
