Lachance D, Garcia R
Clinical Research Institute of Montreal, Quebec, Canada.
Regul Pept. 1991 Jun 11;34(1):55-60. doi: 10.1016/0167-0115(91)90224-5.
The effect of adrenergic stimulation on atrial natriuretic factor (ANF) release was studied in conscious rats. 60 min i.v. infusion of 15 micrograms/kg/min phenylephrine produced an elevation in mean arterial pressure of about 50 mmHg that was associated with an immediate, transitory increase in both central venous (CVP) and left ventricular end-diastolic (LVEDP) pressures. Heart rate was not changed. The elevation in CVP, but not LVEDP, persisted until 5 min, together with a 50-fold increase in plasma C-terminal ANF concentrations (from 19 +/- 5 to 1010 +/- 339 fmol/ml); at 30 min, in the absence of any increases in CVP or LVEDP, plasma ANF was still elevated by 5-fold (114 +/- 35 fmol/ml). It is suggested that adrenergic stimulation 'per se' can induce ANF release, independently of atrial pressure. Furthermore, combined adrenergic stimulation and increased atrial wall tension could result in a potentiation of the ANF secretory response 'in vivo', in the case where both stimuli are present concomitantly.
在清醒大鼠中研究了肾上腺素能刺激对心房利钠因子（ANF）释放的影响。以15微克/千克/分钟的剂量静脉输注去氧肾上腺素60分钟，可使平均动脉压升高约50 mmHg，同时中心静脉压（CVP）和左心室舒张末期压力（LVEDP）立即短暂升高。心率未改变。CVP升高，但LVEDP未升高，持续至5分钟，同时血浆C端ANF浓度增加50倍（从19±5升高至1010±339 fmol/ml）；30分钟时，在CVP或LVEDP无任何升高的情况下，血浆ANF仍升高5倍（114±35 fmol/ml）。提示肾上腺素能刺激“本身”可诱导ANF释放，与心房压力无关。此外，在体内同时存在肾上腺素能刺激和心房壁张力增加的情况下，两者联合可导致ANF分泌反应增强。
