Badanich Kimberly A, Maldonado Antoniette M, Kirstein Cheryl L
Department of Psychology Cognitive and Neural Sciences University of South Florida 4202 E, Fowler Avenue Tampa, FL 33620, USA.
Dev Psychobiol. 2008 Mar;50(2):127-33. doi: 10.1002/dev.20252.
Initiation of drug use during adolescence is associated with an increased probability to develop a drug addiction. The present study examined dose-response effects of cocaine (0, 5, 10, or 20 mg/kg, i.p.) on locomotor activity in early adolescent (postnatal day (PND) 35), late adolescent (PND 45), and young adults (PND 60) by measuring total distance moved (TDM) and frequency of start-stops. In response to 20 mg/kg cocaine, early adolescents showed the greatest cocaine-induced increase in TDM in comparison to late adolescent and adult rats. At this same dose, early adolescents showed the greatest cocaine-induced attenuation of start-stops relative to older rats. Results suggest that early adolescents engage in more cocaine-induced locomotor activity and less stationary behavior indicating that early adolescents are more sensitive to locomotor activating effects of high dose cocaine than older rats.
青春期开始使用毒品与成瘾可能性增加有关。本研究通过测量移动的总距离（TDM）和启停频率，研究了可卡因（0、5、10或20mg/kg，腹腔注射）对青春期早期（出生后第35天（PND 35））、青春期晚期（PND 45）和年轻成年期（PND 60）大鼠运动活动的剂量反应效应。与青春期晚期和成年大鼠相比，在20mg/kg可卡因作用下，青春期早期大鼠的TDM可卡因诱导增加最大。在相同剂量下，与年长大鼠相比，青春期早期大鼠的可卡因诱导的启停衰减最大。结果表明，青春期早期大鼠在可卡因作用下的运动活动更多，静止行为更少，这表明青春期早期大鼠比年长大鼠对高剂量可卡因的运动激活作用更敏感。
