Wedenberg K, Ronquist G, Waldenström A, Ulmsten U
Department of Obstetrics and Gynaecology, University Hospital, Uppsala, Sweden.
Biochim Biophys Acta. 1991 Jun 17;1058(2):147-51. doi: 10.1016/s0005-2728(05)80231-2.
The energy status of the cell is mainly dependent on adenine nucleotides and can be expressed as energy charge (EC). EC is known to be kept at narrow limits near 0.90 under normal conditions in most cells. We recently reported remarkably low EC values in the human uterus under apparent steady-state conditions. The present paper is an extension of previous work. It shows that EC varies in different regions of the uterus in that the isthmic part in pregnant women displays a higher EC than the fundus of the uterus. There were no intergroup differences between non-pregnant and term pregnant women, nor between those who were in active normal labour, dysfunctional labour or those who were not in labour at all. On the other hand, EC in uterine muscle of post-menopausal women showed a significantly lower EC value. Human uterus seems to manage its metabolic requirements under different functional conditions in spite of low ATP and EC values. This suggests that ATP occurs in sufficient amounts to pertinent enzyme reactions, especially ATPases, which means Km values adapted for this unusually low ATP concentration.
细胞的能量状态主要取决于腺嘌呤核苷酸，并可以用能荷（EC）来表示。已知在大多数细胞的正常条件下，能荷保持在接近0.90的狭窄范围内。我们最近报道了在明显的稳态条件下，人类子宫中的能荷值极低。本文是先前工作的扩展。它表明能荷在子宫的不同区域有所变化，即孕妇的峡部能荷高于子宫底部。未怀孕和足月孕妇之间、活跃正常分娩、分娩功能障碍或根本未分娩的孕妇之间，组间没有差异。另一方面，绝经后妇女子宫肌层的能荷值明显较低。尽管三磷酸腺苷（ATP）和能荷值较低，但人类子宫似乎能在不同功能条件下满足其代谢需求。这表明ATP的量足以满足相关酶反应，尤其是ATP酶的需求，这意味着米氏常数（Km值）适应了这种异常低的ATP浓度。
