Wedenberg K, Ronquist G, Waldenström A, Ulmsten U
Department of Obstetrics and Gynecology, Uppsala University Hospital, Sweden.
Biochim Biophys Acta. 1990 Jan 29;1033(1):31-4. doi: 10.1016/0304-4165(90)90190-8.
Six pregnant and 10 non-pregnant patients undergoing Caesarean section and laparatomy, respectively participated in this study which was aimed at determining the energy status of human uterine muscle and comparing it to that of striated muscle from the same individual. Biopsies were taken from the fundus uteri between the ligamenta rotunda and from the rectus abdominis muscle. A low energy charge of 0.55 in pregnant patients and 0.64 in non-pregnant patients was observed in uterine biopsies, compared to the expected value of 0.90 found in rectus biopsies. The main determinant of this finding was a 4-8 times lower level of ATP in uterine biopsies compared to that in rectus biopsies. The same pattern was apparent for total nucleotide content and creatine phosphate. The ADP and AMP contents were of the same order of magnitude in both tissues. The lactate content in uterine biopsies from pregnant patients was significantly higher than that found in biopsies from rectus muscle and from uterine tissue of non-pregnant patients, indicating an increased glycogenolysis in pregnant uterus. The low energy charge and low level of phospho-compounds observed in uterine muscle, regardless of the functional state, are new and unexpected findings.
分别有6名接受剖宫产手术的孕妇和10名接受剖腹手术的非孕妇参与了本研究，该研究旨在确定人类子宫肌肉的能量状态，并将其与同一个体的横纹肌的能量状态进行比较。活检样本取自子宫圆韧带之间的子宫底部和腹直肌。与腹直肌活检样本中预期的0.90相比，子宫活检样本中观察到孕妇的能量电荷为0.55，非孕妇为0.64。这一发现的主要决定因素是子宫活检样本中的ATP水平比腹直肌活检样本中的低4至8倍。总核苷酸含量和磷酸肌酸也呈现相同模式。两种组织中的ADP和AMP含量处于相同数量级。孕妇子宫活检样本中的乳酸含量显著高于腹直肌活检样本以及非孕妇子宫组织活检样本中的乳酸含量，这表明孕妇子宫中的糖原分解增加。无论功能状态如何，子宫肌肉中观察到的低能量电荷和低磷酸化合物水平都是新的意外发现。
