加拿大人群中孕期暴露于美国食品药品监督管理局（FDA）C、D和X类处方药的模式。

Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population.

作者信息

Wen S W, Yang T, Krewski D, Yang Q, Nimrod C, Garner P, Fraser W, Olatunbosun O, Walker M C

机构信息

OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada.

出版信息

J Perinatol. 2008 May;28(5):324-9. doi: 10.1038/jp.2008.6. Epub 2008 Feb 21.

DOI:10.1038/jp.2008.6

PMID:18288118

Abstract

OBJECTIVE

To examine prescription Food and Drug Administration (FDA) C, D and X drugs in general obstetric population.

STUDY DESIGN

Historical cohort study.

RESULT

A total of 18 575 women who gave a birth in Saskatchewan between January 1997 and December 2000 were included. Among them, 3604 (19.4%) received FDA C, D or X drugs at least once during pregnancy. The pregnancy exposure rates were 15.8, 5.2 and 3.9%, respectively, for category C, D and X drugs, and were 11.2, 7.3 and 8.2%, respectively, in the first, second and third trimesters. Salbutamol (albuterol), trimethoprim/sulfamethoxazole (co-trimoxazole), ibuprofen, naproxen and oral contraceptives were the most common C, D, X drugs used during pregnancy.

CONCLUSION

About one in every five women uses FDA C, D and X drugs at least once during pregnancy, and the most common prescription drugs in pregnancy are antiasthmatic, antibiotics, nonsteroid anti-inflammation drugs, antianxiety or antidepressants and oral contraceptives.

摘要

目的

研究普通产科人群中使用美国食品药品监督管理局（FDA）C、D和X类药物的情况。

研究设计

回顾性队列研究。

结果

纳入了1997年1月至2000年12月期间在萨斯喀彻温省分娩的18575名妇女。其中，3604名（19.4%）在孕期至少使用过一次FDA C、D或X类药物。C、D和X类药物的孕期暴露率分别为15.8%、5.2%和3.9%，在孕早期、孕中期和孕晚期分别为11.2%、7.3%和8.2%。沙丁胺醇（舒喘灵）、甲氧苄啶/磺胺甲恶唑（复方新诺明）、布洛芬、萘普生和口服避孕药是孕期最常用的C、D、X类药物。