Arad I, Braunstein R, Netzer D
Department of Neonatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
J Perinatol. 2008 May;28(5):361-7. doi: 10.1038/jp.2008.12. Epub 2008 Feb 21.
To evaluate the association between parents' ethnic/religious affiliation (secular Jewish, religious Jewish, ultra-orthodox Jewish, Muslim Arabs) and survival of premature infants with severe intraventricular hemorrhage (IVH).
Survival of 102 infants (birth weight<or=1500 g) born at the Hadassah hospitals in Jerusalem from 1 January 1996 through 31 December 2005, who sustained severe IVH and who survived over 48 h, was assessed in relation to their parents' ethnic/religious affiliation and accounting for relevant clinical and demographic variables.
There were 38 cases of demise among 72 infants with IVH grade IV (52.8%), and 4 among 30 infants with IVH grade III (13.3%). In a multivariate logistic regression analysis accounting for relevant perinatal variables, the odds for mortality compared to the reference Arab group was significantly lower only with regard to ultra-orthodox patients (odds ratio, OR=0.06; 95% confidential interval, CI=0.00 to 0.80; P=0.033). In a logistic and in the Cox stepwise regression analyses with religion as forced in variable, comparing infants with IVH grade IV of religious and ultra-orthodox Jewish families with those of secular Jewish families, the OR/hazard ratio (HR) for mortality were OR=0.10; 95% CI=0.01 to 0.06; P=0.017, and HR=0.37; 95% CI=0.16 to 0.85; P=0.019, respectively. No significant difference between the groups was demonstrated when infants with IVH grade III were analyzed apart.
Parental religious affiliation may be influential on the outcome of premature infants with severe brain damage.
评估父母的种族/宗教归属（世俗犹太教徒、宗教犹太教徒、极端正统犹太教徒、穆斯林阿拉伯人）与重度脑室内出血（IVH）早产儿存活情况之间的关联。
对1996年1月1日至2005年12月31日在耶路撒冷哈达萨医院出生、患有重度IVH且存活超过48小时的102例婴儿（出生体重≤1500g）的存活情况进行评估，评估内容涉及他们父母的种族/宗教归属，并考虑相关临床和人口统计学变量。
72例IVH 4级婴儿中有38例死亡（52.8%），30例IVH 3级婴儿中有4例死亡（13.3%）。在考虑相关围产期变量的多因素逻辑回归分析中，与作为参照组的阿拉伯人群体相比，仅极端正统派患者的死亡几率显著较低（比值比，OR = 0.06；95%置信区间，CI = 0.00至0.80；P = 0.033）。在将宗教作为强制纳入变量的逻辑回归和Cox逐步回归分析中，比较宗教犹太家庭和极端正统犹太家庭中IVH 4级婴儿与世俗犹太家庭中IVH 4级婴儿的死亡OR/风险比（HR）分别为OR = 0.10；95%CI = 0.01至0.06；P = 0.017，以及HR = 0.37；95%CI = 0.16至0.85；P = 0.019。单独分析IVH 3级婴儿时，各群体之间未显示出显著差异。
父母的宗教归属可能对患有严重脑损伤的早产儿结局有影响。
