Knollmann Björn C, Roden Dan M
Vanderbilt University School of Medicine, 1285 Medical Research Building IV, Nashville, Tennessee 37232, USA.
Nature. 2008 Feb 21;451(7181):929-36. doi: 10.1038/nature06799.
Abnormalities in heart rhythm continue to cause high rates of illness and death. Better treatment could be provided by solving two main challenges: the early identification of patients who are at risk, and the characterization of molecular pathways that culminate in arrhythmias. By analysing mechanisms that increase susceptibility to arrhythmia in individuals with genetic syndromes, it might be possible to improve current therapies and to develop new ways to treat and prevent common arrhythmias.
心律失常异常持续导致高发病率和高死亡率。通过解决两个主要挑战可以提供更好的治疗方法：早期识别有风险的患者，以及确定导致心律失常的分子途径特征。通过分析增加患有遗传综合征个体心律失常易感性的机制，有可能改进当前疗法并开发治疗和预防常见心律失常的新方法。
