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腺病毒E1A蛋白与TATA框结合转录因子IID之间的直接相互作用。

Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID.

作者信息

Horikoshi N, Maguire K, Kralli A, Maldonado E, Reinberg D, Weinmann R

机构信息

Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.

出版信息

Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5124-8. doi: 10.1073/pnas.88.12.5124.

DOI:10.1073/pnas.88.12.5124
PMID:1828892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC51824/
Abstract

Adenovirus E1A has long been known to activate/repress cellular and viral transcription. The transcriptional activity of nuclear extracts was depleted after chromatography on immobilized E1A protein columns that specifically retained the transcription factor (TF) IID. Stronger direct interactions between E1A and human TFIID than between E1A and yeast TFIID suggest that the unique sequences of the human protein may be involved. We have demonstrated that this interaction occurs directly between bacterially produced E1A and bacterially produced human TFIID in a protein blot assay. We propose that E1A protein may transduce regulatory signals from upstream activators to basal elements of the transcriptional machinery by contacting TFIID.

摘要

长期以来，人们一直知道腺病毒E1A可激活/抑制细胞和病毒转录。在固定化E1A蛋白柱上进行层析后，核提取物的转录活性降低，该蛋白柱能特异性保留转录因子（TF）IID。E1A与人TFIID之间的直接相互作用比E1A与酵母TFIID之间的更强，这表明人类蛋白质的独特序列可能参与其中。我们已经证明，在蛋白质印迹分析中，细菌产生的E1A与细菌产生的人TFIID之间直接发生这种相互作用。我们提出，E1A蛋白可能通过与TFIID接触，将来自上游激活剂的调节信号传递给转录机制的基础元件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/aed80a9efdd2/pnas01062-0070-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/b232c5d8a197/pnas01062-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/c364ccc8730f/pnas01062-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/48dfe844aa99/pnas01062-0069-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/e2d508ebd470/pnas01062-0069-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/ae7c280e44ab/pnas01062-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/882e2b5aee00/pnas01062-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/8a3ee1f42d91/pnas01062-0070-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/aed80a9efdd2/pnas01062-0070-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/b232c5d8a197/pnas01062-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/c364ccc8730f/pnas01062-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/48dfe844aa99/pnas01062-0069-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/e2d508ebd470/pnas01062-0069-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/ae7c280e44ab/pnas01062-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/882e2b5aee00/pnas01062-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/8a3ee1f42d91/pnas01062-0070-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6241/51824/aed80a9efdd2/pnas01062-0070-d.jpg

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