微波与平行合成相结合在药物化学中的应用
Applications of the combination of microwave and parallel synthesis in medicinal chemistry.
作者信息
Alcázar Jesús, Dielsb Gaston, Schoentjes Bruno
机构信息
Johnson & Johnson Pharmaceutical Research and Development, Division of Janssen-Cilag, S.A. Jarama 75, Toledo, Spain.
出版信息
Comb Chem High Throughput Screen. 2007 Dec;10(10):918-32. doi: 10.2174/138620707783220383.
The blending of microwave heating and parallel chemistry is a logical consequence of the significant rate enhancement and higher product yield afforded by microwave technology and the increase in productivity afforded by combinatorial chemistry. For this reason, this combination has become increasingly popular in the organic chemistry community. The current review highlights the application of this approach as a way to increase the rate of analogue synthesis in medicinal chemistry.
微波加热与平行化学的结合是微波技术带来的显著速率提升和更高产物产率以及组合化学带来的生产率提高的必然结果。因此，这种结合在有机化学领域越来越受欢迎。本综述重点介绍了这种方法作为提高药物化学中类似物合成速率的一种方式的应用。
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