Lidström Pelle, Westman Jacob, Lewis Anthony
Personal Chemistry Ltd, Lincoln House, The Paddocks, 347 Cherry Hinton Road, Cambridge, CB1 8DH, UK.
Comb Chem High Throughput Screen. 2002 Sep;5(6):441-58. doi: 10.2174/1386207023330147.
It was in the 1980 s that the first papers in which the use of either combinatorial methods or microwave heating in organic chemistry were published. Unlike combinatorial chemistry, which quite readily became an accepted method, particularly in the pharmaceutical industry, it is only now that microwave heating is truly gaining acceptance. Our aim in this review is to attempt to rationalize this slow acceptance and to show the benefits to be gained by employing microwave heating in tandem with combinatorial chemistry. We will also give a number of examples of successful applications.
20世纪80年代，有机化学中首次发表了关于使用组合方法或微波加热的论文。与组合化学不同，组合化学很快就成为一种被广泛接受的方法，尤其是在制药行业，而微波加热直到现在才真正得到认可。我们撰写这篇综述的目的是试图解释这种接受过程缓慢的原因，并展示将微波加热与组合化学结合使用所带来的好处。我们还将给出一些成功应用的例子。
