Morrison T E, Heise M T
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Curr Drug Targets. 2008 Feb;9(2):165-72. doi: 10.2174/138945008783502485.
Arthropod-borne viruses (arboviruses) are a significant cause of human diseases worldwide. Interactions between these viruses and the innate immune system play a major role in determining the outcome of disease. The complement system is particularly important in this process as activation of complement can contribute to both host defense as well as injury to host tissues. This review focuses on the increasing evidence that the complement system plays key roles in both protective and pathologic outcomes of arbovirus infection.
节肢动物传播病毒（虫媒病毒）是全球人类疾病的一个重要病因。这些病毒与先天免疫系统之间的相互作用在决定疾病的转归中起主要作用。补体系统在这一过程中尤为重要，因为补体的激活既能促进宿主防御，也会导致宿主组织损伤。本综述重点关注越来越多的证据表明补体系统在虫媒病毒感染的保护性和病理性转归中均发挥关键作用。
