McCarthy M, Bore J
Department of Community Medicine, University College London, U.K.
Eur J Cancer. 1991;27(5):579-82. doi: 10.1016/0277-5379(91)90222-y.
We compared the initial treatment of 383 patients with breast cancer in two central London teaching hospitals during 1986 with the guidelines of the King's Fund Consensus Conference for breast cancer treatment held in London the same year. The majority of patients (68%) received lumpectomy and 18% received mastectomy. Lumpectomy was followed by radiotherapy for 95% of cases but 30% of mastectomy patients also received radiotherapy. Only 42% of the patients had surgical sampling of the axillary nodes. Cytotoxic chemotherapy was recorded for 27% women under 50, but also for 16% women age 50 or more. Tamoxifen was given to 58% of women aged 50 or more, but also to 26% of women under 50. We conclude that there are discrepancies between consensus guidelines and clinical practice. Further study is needed to determine whether these variations are clinically important, and whether similar variations exist elsewhere in Europe.
我们将1986年伦敦两家中心教学医院的383例乳腺癌患者的初始治疗情况与同年在伦敦举行的国王基金乳腺癌治疗共识会议的指南进行了比较。大多数患者(68%)接受了肿块切除术,18%接受了乳房切除术。95%接受肿块切除术的患者随后接受了放疗,但30%接受乳房切除术的患者也接受了放疗。只有42%的患者进行了腋窝淋巴结手术取样。27%的50岁以下女性接受了细胞毒性化疗,但50岁及以上女性中也有16%接受了化疗。50岁及以上女性中有58%服用了他莫昔芬,但50岁以下女性中也有26%服用了他莫昔芬。我们得出结论,共识指南与临床实践之间存在差异。需要进一步研究以确定这些差异在临床上是否重要,以及欧洲其他地方是否也存在类似差异。