Vidal J, Giard M-H, Roux S, Barthélémy C, Bruneau N
INSERM, U930, Tours, France.
Clin Neurophysiol. 2008 Apr;119(4):763-71. doi: 10.1016/j.clinph.2007.11.178. Epub 2008 Mar 4.
The aim of this study was to investigate in healthy adults the electrophysiological correlates of auditory-visual interactions involved in perception of bimodal events in a no-task paradigm.
Event-related potentials were recorded in response to unimodal auditory (A), unimodal visual (V) and bimodal (AV) stimuli. Cross-modal interactions were estimated using the additive [AV-(A+V)] model.
The spatio-temporal analysis of ERPs and scalp current densities revealed several interaction patterns occurring at both early and late stages of sensory cortical processing: (1) amplitude decrease of the unimodal auditory N1 wave as early as 55ms, (2) amplitude increase of the unimodal auditory P2 wave from 150 to 195ms concomitant with new neural activity over the right fronto-temporal region, and (3) amplitude increase of the late unimodal visual response within 245-350ms post-stimulus.
Our study provides evidence that several patterns of cross-modal interactions can be generated even if no task is required from subjects.
The paradigm used here can thus be utilized for studying the maturation of the cross-modal processes in young children and in children with pathological development.
本研究旨在探究在无任务范式下，健康成年人中参与双峰事件感知的视听交互的电生理相关性。
记录对单峰听觉（A）、单峰视觉（V）和双峰（AV）刺激的事件相关电位。使用相加[AV-(A+V)]模型估计跨模态交互。
对事件相关电位和头皮电流密度的时空分析揭示了在感觉皮层处理的早期和晚期出现的几种交互模式：（1）早在55毫秒时单峰听觉N1波幅下降，（2）在150至195毫秒时单峰听觉P2波幅增加，同时右侧额颞区出现新的神经活动，以及（3）刺激后245-350毫秒内单峰视觉晚期反应的波幅增加。
我们的研究提供了证据，表明即使不要求受试者执行任务，也可以产生几种跨模态交互模式。
因此，这里使用的范式可用于研究幼儿和发育异常儿童跨模态过程的成熟情况。
