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[脱氢表雄酮对去卵巢雌性小鼠攻击哺乳期入侵者反应的抑制作用因新生期雄激素化而增强]

[Inhibition by dehydroepiandrosterone of aggression responses of spayed female mice towards lactating intruders is potentiated by neonatal androgenization].

作者信息

Haug M, Young J, Robel P, Baulieu E E

机构信息

C.N.R.S., U.R.A., 1295, Laboratoire de Psychophysiologie, Strasbourg.

出版信息

C R Acad Sci III. 1991;312(10):511-6.

PMID:1829018
Abstract

Female mice of an inbred Swiss strain were injected subcutaneously (s.c.) with either testosterone propionate or oil-vehicle on the day of birth. Once adult (8 week-old), they were spayed, and then treated either with dehydroepiandrosterone (80 micrograms/day s.c. for 15 days) or with solvent. The decrease of biting attacks by dehydroepiandrosterone was definitely more prominent in neonatally imprinted females than in controls.

摘要

在出生当天,将近交系瑞士品系的雌性小鼠皮下注射丙酸睾酮或油性载体。成年后(8周龄),对它们进行绝育,然后用脱氢表雄酮(每天80微克,皮下注射15天)或溶剂进行处理。脱氢表雄酮对咬斗攻击行为的减少在新生期印记的雌性小鼠中比在对照组中明显更显著。

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