Schlegel M L, Spetz J F, Robel P, Haug M
Physiol Behav. 1985 Jun;34(6):867-70. doi: 10.1016/0031-9384(85)90005-8.
Triads of castrated male mice (residents) were injected each day for 2 weeks with oil vehicle or 280 nmol of dehydroepiandrosterone (D). They were tested for their attack on a lactating female (intruder) introduced in their home-cage 2,24 or 48 hr after their last injection. D significantly reduced male aggressive behavior for at least 24 hr. Other groups of castrated males were injected each day with vehicle or 280 nmol of D, dehydroepiandrosterone sulfate (DS) or androstenediol (ADIOL). D, but neither DS nor ADIOL, significantly reduced their aggressive responses to intruders. Neural levels of D, DS and testosterone (T) were measured in intact males injected with vehicle or D. The concentration of D in brain was unchanged by castration and was increased about 20 fold in D injected males. The concentration of neural T was 10 nmol/g of tissue in intact males, was almost undetectable in castrated males, and was slightly increased in D injected males. Further work will be needed to identify the steroid molecule(s) responsible for this behavioral effect of D.
将去势雄性小鼠（常住者）三只一组，每天注射油剂载体或280纳摩尔脱氢表雄酮（D），持续2周。在最后一次注射后2、24或48小时，对它们攻击放入其饲养笼中的泌乳雌性（入侵者）的行为进行测试。脱氢表雄酮在至少24小时内显著降低了雄性的攻击行为。其他几组去势雄性小鼠每天注射载体、280纳摩尔脱氢表雄酮、硫酸脱氢表雄酮（DS）或雄烯二醇（ADIOL）。脱氢表雄酮，但硫酸脱氢表雄酮和雄烯二醇均未显著降低它们对入侵者的攻击反应。在注射载体或脱氢表雄酮的完整雄性小鼠中测量脱氢表雄酮、硫酸脱氢表雄酮和睾酮（T）的神经水平。脑中脱氢表雄酮的浓度在去势后未改变，在注射脱氢表雄酮的雄性小鼠中增加了约20倍。完整雄性小鼠神经组织中睾酮的浓度为10纳摩尔/克组织，去势雄性小鼠中几乎检测不到，而在注射脱氢表雄酮的雄性小鼠中略有增加。需要进一步的研究来确定导致脱氢表雄酮这种行为效应的甾体分子。
