Kim K-K, Kim D G, Ku Y H, Lee Y J, Kim W-C, Kim O J, Kim H S
Department of Neurology, Pochon CHA University College of Medicine, Seongnam-si, Gyeunggi-do, South Korea.
Eur J Neurol. 2008 Mar;15(3):306-8. doi: 10.1111/j.1468-1331.2007.02025.x.
Sildenafil citrate (Viagra) is one of the frequently prescribed drugs for men with erectile dysfunction. We describe a 52-year-old man with bilateral middle cerebral artery (MCA) territory infarction after sildenafil use. He ingested 100 mg of sildenafil and about 1 h later, he complained of chest discomfort, palpitation and dizziness followed by mental obtundation, global aphasia and left hemiparesis. Brain magnetic resonance imaging documented acute bilateral hemispheric infarction, and cerebral angiography showed occluded bilateral MCA. Despite significant bilateral MCA stenosis and cerebral infarction, systemic hypotension persisted for a day. We presume that cerebral infarction was caused by cardioembolism with sildenafil use.
枸橼酸西地那非（万艾可）是治疗男性勃起功能障碍最常用的处方药之一。我们描述了一名52岁男性，在服用西地那非后出现双侧大脑中动脉（MCA）供血区梗死。他服用了100毫克西地那非，约1小时后，他主诉胸部不适、心悸和头晕，随后出现精神迟钝、完全性失语和左侧偏瘫。脑部磁共振成像显示急性双侧半球梗死，脑血管造影显示双侧MCA闭塞。尽管存在明显的双侧MCA狭窄和脑梗死，但系统性低血压持续了一天。我们推测脑梗死是由服用西地那非导致的心源性栓塞引起的。
