Ahmed Kamran, Hoque Robiol, El-Tawil Sherif, Khan Mohammad S, George Mark L
Department of General Surgery, St Thomas' Hospital, London, UK.
World J Surg Oncol. 2008 Feb 21;6:23. doi: 10.1186/1477-7819-6-23.
Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract. Presentation mimics acute appendicitis, but right iliac fossa mass and intestinal obstruction have also been reported. These presentations reflect various stages of a locally expanding tumour causing luminal obstruction of appendix. The investigation and subsequent management with a review of the literature is presented.
We report a case of appendicular adenocarcinoma found unexpectedly in a 43 year old male who presented with urinary symptoms. Cystoscopy and uretero-renoscopy showed normal bladder but external compression of the ureters and therefore bilateral stents were inserted. CT scan showed a caecal mass. After colonoscopy, that showed external compression, and diagnostic laparoscopy the patient underwent right hemicolectomy. Histopathology revealed well differentiated adenocarcinoma with signet ring morphology with multiple lymph node involvement. The patient was referred for chemotherapy where he received infusional 5 fluorouracil but died 7 months after surgery.
Patients with atypical manifestations related to right lower abdominal quadrant should be thoroughly investigated with an open mind. Every attempt should be made to make a precise diagnosis through all the available means to direct the treatment along correct lines.
阑尾腺癌是一种罕见的胃肠道肿瘤。其临床表现类似急性阑尾炎,但也有右侧髂窝肿块和肠梗阻的报道。这些表现反映了局部扩张性肿瘤导致阑尾管腔梗阻的不同阶段。本文将对相关文献进行综述,并介绍该病例的检查及后续治疗情况。
我们报告一例43岁男性患者,因出现泌尿系统症状意外发现阑尾腺癌。膀胱镜检查和输尿管肾镜检查显示膀胱正常,但输尿管受到外部压迫,因此插入了双侧支架。CT扫描显示盲肠有肿块。结肠镜检查显示外部压迫,经诊断性腹腔镜检查后,患者接受了右半结肠切除术。组织病理学显示为高分化腺癌,伴有印戒样形态,并有多个淋巴结受累。患者被转诊接受化疗,接受了静脉输注5-氟尿嘧啶治疗,但术后7个月死亡。
对于有右下象限非典型表现的患者,应持开放态度进行全面检查。应尽一切努力通过所有可用手段做出准确诊断,以指导正确的治疗方向。