Phan Du H, Teo Joshua Y, Nalliah Sasikaran
Department of General Surgery, Hervey Bay Hospital, Queensland, Australia.
J Surg Case Rep. 2021 Oct 28;2021(10):rjab452. doi: 10.1093/jscr/rjab452. eCollection 2021 Oct.
Signet cell carcinoma of the appendix is the rarest and the most aggressive subtype of appendiceal malignancy, typically presenting with non-specific symptoms. We describe a case of a 62-year-old male with large bowel obstruction, with computed tomography demonstrating dilated large bowels from caecum to proximal sigmoid colon and pneumoperitoneum. Intraoperatively, closed loop obstruction caused by dense adherence of sigmoid colon to caecum was noted, which had resulted in caecal perforation. Histopathology study indicated primary appendiceal malignancy of signet cell morphology with intraperitoneal spread to sigmoid colon. Large bowel obstruction from appendiceal malignancy has rarely been reported and similar presentations have not been described in the existing literature. When left-sided large bowel obstruction is suspected to be caused by a malignant stricture, it is essential to consider transperitoneal spread of appendiceal malignancy as potential aetiology, particularly in the elderly.
阑尾印戒细胞癌是阑尾恶性肿瘤中最罕见且侵袭性最强的亚型,通常表现为非特异性症状。我们描述了一例62岁男性大肠梗阻病例,计算机断层扫描显示盲肠至乙状结肠近端的大肠扩张及气腹。术中发现乙状结肠与盲肠紧密粘连导致闭袢性梗阻,进而引起盲肠穿孔。组织病理学研究表明为印戒细胞形态的原发性阑尾恶性肿瘤并腹膜内播散至乙状结肠。阑尾恶性肿瘤导致的大肠梗阻鲜有报道,现有文献中也未描述过类似表现。当怀疑左侧大肠梗阻由恶性狭窄引起时,必须考虑阑尾恶性肿瘤的腹膜播散作为潜在病因,尤其是在老年人中。