迈向金黄色葡萄球菌壁磷壁酸生物合成途径。
Toward the pathway of S. aureus WTA biosynthesis.
作者信息
Xia Guoqing, Peschel Andreas
机构信息
Cellular and Molecular Microbiology Section, Medical Microbiology and Hygiene Department, University of Tübingen, Elfriede-Aulhorn-Strasse 6, 72076 Tübingen, Germany.
出版信息
Chem Biol. 2008 Feb;15(2):95-6. doi: 10.1016/j.chembiol.2008.02.005.
Wall teichoic acid (WTA) contributes profoundly to the virulence of Staphylococcus aureus. The successful in vitro reconstitution of poly-ribitolphosphate WTA biosynthesis using recombinant enzymes sheds new light on WTA enzymology and paves the way for developing new antibiotics that target WTA biosynthesis, as discussed in Brown et al. in a recent issue of Chemistry & Biology.
壁磷壁酸（WTA）对金黄色葡萄球菌的毒力有深远影响。如布朗等人在最近一期《化学生物学》中所讨论的，利用重组酶在体外成功重建聚核糖醇磷酸WTA生物合成，为WTA酶学研究带来了新的启示，并为开发针对WTA生物合成的新型抗生素铺平了道路。
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