天然产物生物合成中的卤化策略。

Halogenation strategies in natural product biosynthesis.

作者信息

Neumann Christopher S, Fujimori Danica Galonić, Walsh Christopher T

机构信息

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Chem Biol. 2008 Feb;15(2):99-109. doi: 10.1016/j.chembiol.2008.01.006.

DOI:10.1016/j.chembiol.2008.01.006

PMID:18291314

Abstract

Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation is also known to proceed through both enzymatic and nonenzymatic pathways. In this article, we review the current state of knowledge regarding the mechanisms of these transformations, highlight applications of this knowledge, and propose future opportunities and challenges for the field.

摘要

卤化是次生代谢产物常见的修饰方式，在确立化合物的生物活性方面可能发挥重要作用。通过氧化机制进行的酶促卤化是这些代谢产物最常见的生成途径，不过经由卤化物阴离子掺入的直接卤化也已知可通过酶促和非酶促途径进行。在本文中，我们综述了关于这些转化机制的当前知识状况，强调了该知识的应用，并提出了该领域未来的机遇和挑战。