[Activity of plasma atrial natriuretic peptide level during acute rejection of kidney transplantation].

Plasma atrial natriuretic peptide (ANP) in 51 kidney transplant patients (KTP) during acute rejection (AR) was measured. All 51 KTP were divided in 3 groups. In the first group (16 subjects) patients were treated by azathioprine, predinisone and promethazine, in the second group (16 subjects) patients were treated by cyclosporine A and prednisone however in the third group (19 subjects) patients were treated by cyclosporine A, azathioprine and prednisone. Control group contained 15 subjects. ANP levels in KTP were measured four times: First time nearly 3 days before AR, second time immediately after recognition AR, third time after 3 days methylprednisone therapy and 4th time 3 days after stopping methylprednisone therapy. In all KTP before rejection ANP levels were slightly enhanced. During AR was observed statistically significant increase ANP levels in all KTP. After methylprednisone therapy plasma ANP level returned to basal (before rejection) level. Only before rejection a significant positive correlation was found between ANP and kidney function. All our result suggests participation of factors other than wicked kidney function in the pathogenesis enhanced ANP levels during AR. Kind of immunosuppressive therapy seems only a slightly influence on ANP levels in KTP before and after AR.