Zukowska-Szczechowska E, Kokot F, Grzeszczak W, Wocial B
Katedry i Kliniki Nefrologii Slaskiej Akademii Medycznej w Katowicach.
Pol Arch Med Wewn. 1991 Oct;86(4):254-62.
In 64 kidney transplant patients (KTP) (35) treated by cyclosporine A (CyA)+ prednisone and 29 treated by azathioprine (Aza)+ prednisone and promethazine and in 15 healthy subjects plasma adrenalin (A), noradrenaline (NA), plasma renin activity (PRA) and mean arterial pressure (MAP) in basal conditions and after water immersion test (WI) were measured. In basal conditions the A and PRA were higher, but NA was normal. After WI statistically significant decrease of MAP, PRA, A and NA were observed in all examined groups. In KTP mean decrease MAP, PRA and A was higher, but NA lower than in normals. No significant correlation between A or NA and PRA, and MAP and A or NA was observed. In KTP the change in sympathetic+ activity was observed. Participation of catecholamines and renin in the pathogenesis of hypertension in KTP is not dominant. Kind of immunosuppressive therapy (CyA or Aza) haven't significant influence on A, NA nad PRA levels.
对64例接受环孢素A（CyA）+泼尼松治疗的肾移植患者（KTP）（35例）、29例接受硫唑嘌呤（Aza）+泼尼松及异丙嗪治疗的肾移植患者以及15名健康受试者，测量了基础状态下以及水浸试验（WI）后的血浆肾上腺素（A）、去甲肾上腺素（NA）、血浆肾素活性（PRA）和平均动脉压（MAP）。在基础状态下，A和PRA较高，但NA正常。水浸试验后，所有检查组的MAP、PRA、A和NA均出现统计学显著下降。肾移植患者中MAP、PRA和A的平均下降幅度较高，但NA低于正常人。未观察到A或NA与PRA之间以及MAP与A或NA之间存在显著相关性。在肾移植患者中观察到交感神经活性的变化。儿茶酚胺和肾素在肾移植患者高血压发病机制中的作用不占主导地位。免疫抑制治疗类型（CyA或Aza）对A、NA和PRA水平无显著影响。
