Miossec P
Laboratoire d'Immunologie, INSERM U 80, Hôpital E.-Herriot, Lyon.
Presse Med. 1991 Jun 1;20(21):997-1001.
Increased levels of the soluble form of the low-affinity receptor for interleukin 2 have been found in various clinical situations associated with immune system activation: infections, haematological disorders, autoimmune diseases, graft rejection, etc. Increased levels are usually associated with a higher stage of activity of the disease and correlated with a more severe prognosis. Reduction of levels precedes the treatment-induced clinical improvement. However, the prognostic value of these fluctuations might be limited by the level increases induced by infections. The immunological role of this receptor remains to be demonstrated and is probably not limited to interleukin 2 binding.
在与免疫系统激活相关的各种临床情况中，如感染、血液系统疾病、自身免疫性疾病、移植排斥等，已发现白细胞介素2低亲和力受体可溶性形式的水平升高。水平升高通常与疾病的更高活动阶段相关，并与更严重的预后相关。水平降低先于治疗引起的临床改善。然而，这些波动的预后价值可能会受到感染引起的水平升高的限制。该受体的免疫作用仍有待证实，可能不限于白细胞介素2结合。
