Zerler B
Molecular Therapeutics, Inc., Miles Research Center, West Haven, Connecticut 06516.
Cancer Cells. 1991 Dec;3(12):471-9.
Activation of T cells is associated with a dramatic increase in expression of the interleukin-2 receptor. In addition to the intact receptor found at the cell surface, activated T cells produce a truncated form of the receptor (sIL-2R) that is secreted as a soluble molecule. Patients with neoplastic disease or diseases involving immune activation exhibit markedly elevated serum levels of sIL-2R. Although the functional significance of sIL-2R is unknown, the ability to measure this parameter rapidly and accurately in serum samples makes it a potentially useful index for monitoring disease activity. Recent studies indicate that a rise in serum levels of sIL-2R in apparently healthy individuals could be an important early signal of neoplastic, autoimmune, or inflammatory disease. Moreover, subsequent to diagnosis, serum levels of sIL-2R appear to be a reliable indicator of tumor burden and therapeutic response for many patients with leukemia and lymphoma, an indicator of metastasis for patients with solid tumors, and an indicator of exacerbation and clinical response in patients with diseases associated with immune activation.
T细胞的激活与白细胞介素-2受体表达的显著增加有关。除了在细胞表面发现的完整受体外，活化的T细胞还产生一种受体的截短形式（sIL-2R），它作为一种可溶性分子被分泌出来。患有肿瘤疾病或涉及免疫激活疾病的患者血清中sIL-2R水平明显升高。尽管sIL-2R的功能意义尚不清楚，但能够在血清样本中快速准确地测量这一参数使其成为监测疾病活动的一个潜在有用指标。最近的研究表明，在看似健康的个体中血清sIL-2R水平的升高可能是肿瘤、自身免疫或炎症性疾病的一个重要早期信号。此外，在诊断之后，血清sIL-2R水平似乎是许多白血病和淋巴瘤患者肿瘤负荷和治疗反应的可靠指标，是实体瘤患者转移的指标，也是免疫激活相关疾病患者病情加重和临床反应的指标。
