乳腺癌患者血浆脂质谱水平改变的意义

Significance of alterations in plasma lipid profile levels in breast cancer.

作者信息

Patel Hiten R H

机构信息

Biochemistry Research Division, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India.

出版信息

Integr Cancer Ther. 2008 Mar;7(1):33-41. doi: 10.1177/1534735407313883.

DOI:10.1177/1534735407313883

PMID:18292593

Abstract

HYPOTHESES

The relationship between lipids and breast cancer is obscure. Until now, conflicting results have been reported on the association between lipids and risk of breast cancer in women. Therefore, the major aim of this study is to examine the role of alterations in lipid profile in breast cancer.

STUDY DESIGN

Plasma lipids (ie, total cholesterol [TC], high-density lipoprotein [HDL], low-density lipoprotein [LDL], very-low-density lipoprotein [VLDL], and triglycerides [TG]) were analyzed from 70 controls, 30 patients with benign breast disease (BBD), 125 untreated breast cancer patients, and 93 posttreatment follow-up samples.

METHODS

Samples were analyzed using highly sensitive and specific spectrophotometric methods.

RESULTS

Plasma TC, LDL, VLDL, and TG were significantly lower (p = .042, p = .003, p = .024, p = .014, respectively) in patients with BBD compared with controls. Plasma TC and HDL were significantly lower (p = .026, p = .0001, respectively), and VLDL and TG were significantly higher (p = .009, p = .05) in breast cancer patients as compared with controls. Plasma VLDL and TG were significantly higher in breast cancer patients as compared with patients with BBD. The receiver-operating characteristic curve showed that plasma TC, LDL, VLDL, and TG levels could significantly discriminate (p = .001, p = .005, p = .005, p = .005, respectively) between controls and patients with BBD. Plasma levels of TC, HDL, VLDL, and TG could significantly distinguish (p = .01, p = .002, p = .001, p = .002, respectively) between controls and breast cancer patients. Plasma levels of VLDL and TG could significantly discriminate (p = .000, p = .000, respectively) between patients with BBD and breast cancer patients. Odds ratio analysis revealed that higher levels of TC and HDL were significantly associated with a reduction in breast cancer risk (p = .01 and p = .0001, respectively), whereas higher levels of VLDL and TG were significantly associated with increased breast cancer risk (p = .001 and p = .002, respectively). Plasma VLDL and TG levels were significantly lower in complete responders as compared with pretreatment levels (p = .000, p = .000, respectively), and plasma TC and LDL levels were significantly lower in nonresponders as compared with pretreatment levels (p = .015, p = .009, respectively).

CONCLUSION

The alterations in lipid profile levels showed a significant correlation with breast cancer risk, disease status, and treatment outcome.

摘要

假设

脂质与乳腺癌之间的关系尚不明确。迄今为止，关于女性脂质与乳腺癌风险之间的关联，已有相互矛盾的研究结果报道。因此，本研究的主要目的是探讨脂质谱改变在乳腺癌中的作用。

研究设计

对70名对照者、30名良性乳腺疾病（BBD）患者、125名未经治疗的乳腺癌患者以及93份治疗后随访样本的血浆脂质（即总胆固醇[TC]、高密度脂蛋白[HDL]、低密度脂蛋白[LDL]、极低密度脂蛋白[VLDL]和甘油三酯[TG]）进行分析。

方法

采用高灵敏度和特异性的分光光度法对样本进行分析。

结果

与对照者相比，BBD患者的血浆TC、LDL、VLDL和TG显著降低（分别为p = 0.042、p = 0.003、p = 0.024、p = 0.014）。与对照者相比，乳腺癌患者的血浆TC和HDL显著降低（分别为p = 0.026、p = 0.0001），而VLDL和TG显著升高（分别为p = 0.009、p = 0.05）。与BBD患者相比，乳腺癌患者的血浆VLDL和TG显著升高。受试者工作特征曲线显示，血浆TC、LDL、VLDL和TG水平能够显著区分对照者与BBD患者（分别为p = 0.001、p = 0.005、p = 0.005、p = 0.005）。血浆TC、HDL、VLDL和TG水平能够显著区分对照者与乳腺癌患者（分别为p = 0.01、p = 0.002、p = 0.001、p = 0.002）。血浆VLDL和TG水平能够显著区分BBD患者与乳腺癌患者（分别为p = 0.000、p = 0.000）。优势比分析显示，较高水平的TC和HDL与乳腺癌风险降低显著相关（分别为p = 0.01和p = 0.0001），而较高水平的VLDL和TG与乳腺癌风险增加显著相关（分别为p = 0.001和p = 0.002）。与治疗前水平相比，完全缓解者的血浆VLDL和TG水平显著降低（分别为p = 0.000、p = 0.000），而无反应者的血浆TC和LDL水平与治疗前水平相比显著降低（分别为p = 0.015、p = 0.009）。