Akuyam A, Isah H S, Ogala W N
Department of Chemical Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Niger Postgrad Med J. 2008 Sep;15(3):192-6.
BACKGROUND/OBJECTIVE: There is paucity of data on the pattern of serum lipids in malnourished children in Zaria. Most of the reported studies were carried out in southern part of Nigeria. The overall objective of this study was therefore to measure serum lipids in children with PEM in Zaria with the view to recommending its use in them.
SUBJECTS, MATERIALS AND METHODS: Serum lipids were measured in 115 children presenting with PEM and 115 age- and sex-matched well nourished controls aged 6-36 months .The malnourished children consisted of 25, 30, 30 and 30 children with kwashiorkor, marasmic-kwashiorkor, marasmus and underweight respectively. There were 60 males and 55 females. Serum total cholesterol(TC),high density lipoprotein cholesterol (HDL-C) and triglyceride(TG) were measured by enzymatic colorimetric methods of serum low density lipoprotein cholesterol(LDL-C) and very low density lipoprotein cholesterol(VLDL-C) were estimated using Friedewald formula.
Serum TC, LDL-C and HDL-C levels were significantly lower (p<0.01, p<0.05 and p<0.001 respectively), while the ratio TC/HDL-C was significantly higher (p<0.001) in children with PEM than in their well-nourished counterparts. Concentrations of serum TG and VLDL-C were apparently but not significantly lower in children with PEM than in well-fed children (p>0.05).Serum levels of TC, LDL-C and HDL-C were significantly higher (p<0.001, p<0.001 and p<0.01 respectively) in oedematous PEM patients than in their non-oedematous counterparts. Serum TG and VLDL-C values were apparently but not significantly higher in oedematous PEM patients than in non-oedematous ones.
There was a significant reduction in serum lipid concentrations in children with PEM. The study therefore suggests that measurement of serum lipids could be of importance in the assessment of childhood malnutrition.
背景/目的：关于扎里亚营养不良儿童的血脂模式的数据匮乏。大多数已报道的研究是在尼日利亚南部进行的。因此，本研究的总体目标是测量扎里亚患有蛋白质-能量营养不良（PEM）儿童的血脂，以期推荐将其用于这些儿童。
对象、材料与方法：对115名患有PEM的儿童以及115名年龄和性别匹配、营养良好的6至36个月大的对照儿童进行血脂测量。营养不良儿童分别包括25名夸希奥科病、30名消瘦型夸希奥科病、30名消瘦症和30名体重不足的儿童。其中有60名男性和55名女性。采用酶比色法测定血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG），使用弗里德瓦尔德公式估算血清低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）。
与营养良好的儿童相比，患有PEM的儿童血清TC、LDL-C和HDL-C水平显著降低（分别为p<0.01、p<0.05和p<0.001），而TC/HDL-C比值显著升高（p<0.001）。患有PEM的儿童血清TG和VLDL-C浓度明显但无显著低于营养良好的儿童（p>0.05）。水肿型PEM患者的血清TC、LDL-C和HDL-C水平显著高于非水肿型患者（分别为p<0.001、p<0.001和p<0.01）。水肿型PEM患者的血清TG和VLDL-C值明显但无显著高于非水肿型患者。
患有PEM的儿童血清脂质浓度显著降低。因此，该研究表明测量血清脂质可能对评估儿童营养不良具有重要意义。
