Cottagnoud Philippe
Department of Internal Medicine, Inselspital, Bern, Switzerland.
Swiss Med Wkly. 2008 Feb 23;138(7-8):93-9. doi: 10.4414/smw.2008.12045.
Daptomycin, a new lipopeptide antibiotic, is highly bactericidal against the majority of Gram-positive human pathogens, including methicillin-resistant (MRSA) and vancomycin-resistant enterococci. Its mechanism of action is unique resulting in the destruction of the membrane potential without lysing the cell wall. The mechanism of action of daptomycin, its antibacterial spectrum, the development of resistance and pre- and clinical studies are discussed in this review.
达托霉素是一种新型脂肽类抗生素，对大多数革兰氏阳性人类病原体具有高度杀菌活性，包括耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌。其作用机制独特，可在不裂解细胞壁的情况下破坏膜电位。本文综述了达托霉素的作用机制、抗菌谱、耐药性的产生以及临床前和临床研究情况。
