阿替洛尔可降低孕期和哺乳期接受治疗的自发性高血压大鼠和正常血压大鼠幼崽的唾液分泌活动。
Atenolol reduces salivary activity in pups of spontaneously hypertensive and normotensive rats treated during pregnancy and lactation.
作者信息
Elias Gracieli P, Sassaki Kikue T, Delbem Alberto C B, Antoniali Cristina
机构信息
Pediatric Dentistry Postgraduate Program, School of Dentistry at Araçatuba, São Paulo State University, UNESP, SP, Brazil.
出版信息
Clin Exp Hypertens. 2008 Feb;30(2):133-41. doi: 10.1080/10641960801931923.
The salivary activity in pups of spontaneously hypertensive rats (SHR) and Wistar (W) rats treated with atenolol during pregnancy, and lactation was evaluated. Atenolol's anti-hypertensive effect on the SHR rats was noticed from the beginning of treatment. Atenolol-treated SHR and Wistar rat pups showed a decrease in salivary gland weight, salivary flow, and protein concentration, with no alteration in salivary amylase activity. Atenolol's effect on salivary glands can interfere with oral health maintenance.
对妊娠和哺乳期接受阿替洛尔治疗的自发性高血压大鼠（SHR）和Wistar（W）大鼠幼崽的唾液活性进行了评估。从治疗开始就注意到阿替洛尔对SHR大鼠的抗高血压作用。用阿替洛尔治疗的SHR和Wistar大鼠幼崽的唾液腺重量、唾液流量和蛋白质浓度均降低，而唾液淀粉酶活性没有改变。阿替洛尔对唾液腺的作用可能会干扰口腔健康的维持。
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