Richer C, Boissier J R, Giudicelli J F
Eur J Pharmacol. 1978 Feb 15;47(4):393-400. doi: 10.1016/0014-2999(78)90119-x.
Changes in systolic blood pressure (SBP), heart rate (HR), heart rate and plasma renin concentration (PRC) have been compared in three different groups of rats between the ages of 5 and 20 weeks. The groups were: spontaneously hypertensive rats (SHRs), atenolol-treated SHRs (200 mg/kg/day orally throughout the 15 weeks) and normotensive rats of the same strain (WKYs). Treatment with atenolol markedly inhibited the onset of genetic hypertension, reduced HR and PRC from the outset and diminished the heart weight/body weight ratio. Comparison of changes in these parameters in atenolol-treated SHRs, control SHRs and WKYs strongly suggests that the mechanism of atenolol's preventive action against hypertension development in SHRs primarily involves its effects on heart and on the renin--angiotensin system.
对5至20周龄的三组不同大鼠的收缩压（SBP）、心率（HR）、心率及血浆肾素浓度（PRC）变化进行了比较。这三组分别为：自发性高血压大鼠（SHR）、阿替洛尔治疗的SHR（在整个15周内每日口服200mg/kg）以及同一品系的正常血压大鼠（WKY）。阿替洛尔治疗显著抑制了遗传性高血压的发作，从一开始就降低了HR和PRC，并减小了心脏重量/体重比。比较阿替洛尔治疗的SHR、对照SHR和WKY这些参数的变化强烈表明，阿替洛尔对SHR高血压发展的预防作用机制主要涉及其对心脏和肾素 - 血管紧张素系统的影响。
