Fujinami Y, Fukui T, Nakano K, Ara T, Fujigaki Y, Imamura Y, Hattori T, Yanagisawa S, Kawakami T, Wang P-L
Department of Pharmacology, Graduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Oral Dis. 2009 Oct;15(7):466-71. doi: 10.1111/j.1601-0825.2009.01572.x. Epub 2009 Jun 4.
Passive smoking is the involuntary inhalation of cigarette smoke (CS) and has an adverse impact on oral health. We examined the effect of CS exposure on saliva and salivary glands (SGs).
Cigarette smoke-exposed rats were intermittently housed in an animal chamber with whole-body exposure to CS until killed. Whole saliva was collected before CS exposure (0 day), and 15 and 30 days after the start of CS exposure. Saliva secretion was stimulated by administration of isoproterenol and pilocarpine after anesthesia. SGs were collected on 31 days.
The increase in body weight of the CS-exposed rats was less than that of the control rats. Salivary flow rates did not differ at 0, 15 or 30 days after the start of CS exposure. However, the amylase and peroxidase activities and total protein content in the saliva were significantly lower in 15-day CS-exposed rats than in 15-day control rats. Histological examination of the SGs of CS-exposed rats showed vacuolar degeneration, vasodilation and hyperemia.
These results suggest that CS exposure has adverse impacts on salivary composition and SGs, which could aggravate the oral environment.
被动吸烟是指非自愿吸入香烟烟雾（CS），对口腔健康有不利影响。我们研究了CS暴露对唾液和唾液腺（SGs）的影响。
将暴露于香烟烟雾的大鼠间歇性饲养在动物舱中，全身暴露于CS中直至处死。在CS暴露前（0天）、CS暴露开始后15天和30天收集全唾液。麻醉后通过给予异丙肾上腺素和毛果芸香碱刺激唾液分泌。在第31天收集唾液腺。
暴露于CS的大鼠体重增加少于对照大鼠。CS暴露开始后0、15或30天唾液流速无差异。然而，暴露于CS 15天的大鼠唾液中的淀粉酶和过氧化物酶活性以及总蛋白含量显著低于暴露15天的对照大鼠。对暴露于CS的大鼠唾液腺的组织学检查显示有空泡变性、血管扩张和充血。
这些结果表明，CS暴露对唾液成分和唾液腺有不利影响，这可能会加重口腔环境问题。
