Hufnagl C, Hitzl W, Hornykewycz K, Grabner G, Reitsamer H A
Augenheilkunde und Optometrie, Universitätsklinik der Salzburger Landeskliniken, Salzburg.
Klin Monbl Augenheilkd. 2008 Feb;225(2):151-4. doi: 10.1055/s-2007-963789.
The aim of this study was to compare central corneal thickness (CCT) and intraocular pressure in patients participating in a glaucoma screening programme and patients who were examined in the glaucoma unit.
406 patients of a glaucoma screening programme (Salzburg-Moorfields collaborative glaucoma study) were included in this study. In addition a group of 406 patients who were admitted to the glaucoma clinic for a detailed glaucoma examination was included (outpatient clinic group). In all participants central corneal thickness (CCT) was measured and possible relations of CCT within the study groups were statistically analysed.
In the population screening group the mean central corneal thickness in normal subjects was 536+/-4.3 microm, in patients with ocular hypertension (OHT) 552+/-5.7 microm, patients suffering from a normal tension glaucoma (NTG) showed a mean CCT of 534+/-14.2 microm and those with primary open angle glaucoma (POAG) had a value of 521+/-17.9 microm. In the 'outpatient clinic group' the OHT subgroup had a mean CCT of 553+/-6.8 microm, the NTG subgroup of 529+/-26.5 microm and the one with POAG had a mean of 527+/-19.8 microm. In addition, CCT was measured in all glaucoma patients whose "partner" eye was healthy (544+/-5 microm) and included in this study as part of the normal subgroup. In both groups (screening group and outpatient group), CCT was significantly higher in OHT patients than in normals. In contrast, no statistically significant difference between normals and NTG or POAG patients was detected. Intraocular pressure was significantly lower in the screening groups than in the other ones.
Our data confirm the previously published results concerning OHT and healthy subjects. In this study no significant difference between NTG or POAG subjects and normal eyes was detected. The lower IOP in the screening population can be explained by the fact that patients contacting the screening program are self selected whereas patients of the glaucoma unit are admitted by practising ophthalmologists and are, therefore, rather advanced cases or carrying special risk factors.
本研究旨在比较参加青光眼筛查项目的患者与在青光眼科室接受检查的患者的中央角膜厚度（CCT）和眼压。
本研究纳入了406例青光眼筛查项目（萨尔茨堡-摩尔菲尔德协作性青光眼研究）的患者。此外，还纳入了一组406例因进行详细青光眼检查而入住青光眼门诊的患者（门诊组）。对所有参与者测量中央角膜厚度（CCT），并对研究组内CCT的可能关系进行统计学分析。
在人群筛查组中，正常受试者的平均中央角膜厚度为536±4.3微米，高眼压症（OHT）患者为552±5.7微米，正常眼压性青光眼（NTG）患者的平均CCT为534±14.2微米，原发性开角型青光眼（POAG）患者的值为521±17.9微米。在“门诊组”中，OHT亚组的平均CCT为553±6.8微米，NTG亚组为529±26.5微米，POAG亚组的平均CCT为527±19.8微米。此外，对所有“对侧”眼健康的青光眼患者测量了CCT（544±5微米），并将其作为正常亚组的一部分纳入本研究。在两组（筛查组和门诊组）中，OHT患者的CCT均显著高于正常受试者。相比之下，正常受试者与NTG或POAG患者之间未检测到统计学上的显著差异。筛查组的眼压显著低于其他组。
我们的数据证实了先前发表的关于OHT和健康受试者的结果。在本研究中，未检测到NTG或POAG受试者与正常眼之间的显著差异。筛查人群中较低的眼压可以通过以下事实来解释：参加筛查项目的患者是自我选择的，而青光眼科室的患者是由执业眼科医生收治的，因此，他们多为病情较严重的病例或具有特殊危险因素。
