Liu Xing, Zeng Yang-fa, Huang Jing-jing, Zheng Xiao-ping, Ling Yun-lan, Cai Xiao-yu
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Zhonghua Yan Ke Za Zhi. 2006 Mar;42(3):199-203.
To evaluate central corneal thickness (CCT) of normal subjects, patients with primary open angle glaucoma (POAG), normal tension glaucoma (NTG) and ocular hypertension (OHT) using optical coherence tomography (OCT).
One hundred and forty-three eyes of 143 normal subjects, 36 eyes of 36 patients with POAG, 39 eyes of 39 patients with NTG and 40 eyes of 40 patients with OHT were enrolled. CCT were measured by OCT3 and analyzed using ANOVA. The relationship of CCT and intraocular pressure (IOP) measured by Goldmann applanation tonometry were analyzed by linear regression. The inter-observer and intra-observer agreement of CCT measurement by OCT were analyzed by interclass correlation coefficient (ICC).
The average CCT of normal subjects, patients with POAG, NTG and OHT were (525.31 +/- 32.18) microm, (531.87 +/- 31.58) microm, (507.61 +/- 21.56) microm and (574.09 +/- 27.84) microm, respectively. There was no significant difference between normal subjects and patients with POAG (P = 0.099). The average CCT of OHT patients was larger than those of other groups (P < 0.001). The average CCT of patients with NTG was less than those of other groups (P < 0.001). There was positive relationship between CCT and IOP in normal subjects (r = 0.318, R2 = 0.101, P < 0.001). The ICC of inter-observer and intra-observer agreement of CCT measurement by OCT were 0.995 and 0.996 respectively.
Central corneal thickness could be measured by OCT accurately. The average CCT in the patients with NTG was thinner, but the average CCT in the patients with OHT was thicker than that of normal subjects. CCT could affect IOP measurement in the application of Goldmann applanation tonometry but with little significant.
使用光学相干断层扫描（OCT）评估正常受试者、原发性开角型青光眼（POAG）患者、正常眼压性青光眼（NTG）患者及高眼压症（OHT）患者的中央角膜厚度（CCT）。
纳入143名正常受试者的143只眼、36名POAG患者的36只眼、39名NTG患者的39只眼以及40名OHT患者的40只眼。使用OCT3测量CCT，并采用方差分析进行分析。通过线性回归分析CCT与用Goldmann压平眼压计测量的眼压（IOP）之间的关系。通过组内相关系数（ICC）分析OCT测量CCT的观察者间及观察者内一致性。
正常受试者、POAG患者、NTG患者及OHT患者的平均CCT分别为（525.31±32.18）微米、（531.87±31.58）微米、（507.61±21.56）微米和（574.09±27.84）微米。正常受试者与POAG患者之间无显著差异（P = 0.099）。OHT患者的平均CCT大于其他组（P < 0.001）。NTG患者的平均CCT小于其他组（P < 0.001）。正常受试者中CCT与IOP呈正相关（r = 0.318，R2 = 0.101，P < 0.001）。OCT测量CCT的观察者间及观察者内一致性的ICC分别为0.995和0.996。
OCT可准确测量中央角膜厚度。NTG患者的平均CCT较薄，而OHT患者的平均CCT比正常受试者厚。在应用Goldmann压平眼压计时，CCT会影响IOP测量，但影响较小。
