Lakshmi R, Kundu R, Thomas E, Mansuri A P
Department of Biosciences, Saurashtra University, Gujarat, India.
Ecotoxicol Environ Saf. 1991 Feb;21(1):18-24. doi: 10.1016/0147-6513(91)90003-8.
This paper deals with the toxicity of mercuric chloride to different ATPases in the intestine of mudskipper (Boleophthalmus dentatus). Mudskippers were exposed to four sublethal concentrations of mercuric chloride for three durations. The specific activities of Na+, K(+)-ATPase, Ca(2+)-ATPase, Mg(2+)-ATPase, Ca2+, HCO3(-)-ATPase, and Mg2+, HCO3(-)-ATPase were estimated. There was linear inhibition of all the enzymes with increasing mercuric chloride concentration as well as exposure duration. The Na+,K(+)-ATPase was found to be the enzyme most affected, followed by other ion-dependent ATPases. Inhibition of all the enzymes indicates severe damage to the intestinal cells, resulting in a blockage of the transport of substances across the membrane.
本文研究了氯化汞对弹涂鱼（齿弹涂鱼）肠道中不同ATP酶的毒性。将弹涂鱼暴露于四种亚致死浓度的氯化汞中，持续三个时间段。测定了Na +、K(+)-ATP酶、Ca(2+)-ATP酶、Mg(2+)-ATP酶、Ca2+、HCO3(-)-ATP酶和Mg2+、HCO3(-)-ATP酶的比活性。随着氯化汞浓度和暴露时间的增加，所有酶均呈线性抑制。发现Na +、K(+)-ATP酶是受影响最大的酶，其次是其他离子依赖性ATP酶。所有酶的抑制表明肠道细胞受到严重损伤，导致物质跨膜运输受阻。
