氯化汞对背眼弓背鱼组织ATP酶的体内效应。

In vivo effect of mercuric chloride on tissue ATPases of Notopterus notopterus.

作者信息

Verma S R, Jain M, Tonk I P

出版信息

Toxicol Lett. 1983 May;16(3-4):305-9. doi: 10.1016/0378-4274(83)90191-1.

Abstract

Effect of sublethal concentrations, 0.088, 0.044, 0.029, 0.022 and 0.0176 mg HgCl2 per liter (1/5, 1/10, 1/15, 1/20, and 1/25 fractions of 96-h LC50) on Na+-K+, Mg2+, and total ATPase activities in brain, gills, kidney and liver of Notopterus notopterus have been studied after 30 days exposure. Na+-K+ ATPase were inhibited maximally and significantly in brain and minimally and insignificantly in liver. Mg2+ ATPase was inhibited maximally and significantly (P less than 0.01) in brain and minimally and insignificantly in kidney. The relative inhibition of total, Na+-K+ and Mg2+ ATPases for the tissues studied were brain greater than gill greater than kidney greater than liver. At the concentration (1/25 fraction) the enzyme activity returned to the normal range.

摘要

研究了亚致死浓度（每升0.088、0.044、0.029、0.022和0.0176毫克氯化汞，即96小时半数致死浓度的1/5、1/10、1/15、1/20和1/25）对背眼弓背鱼脑、鳃、肾和肝脏中钠钾、镁以及总ATP酶活性的影响，暴露30天后进行测定。钠钾ATP酶在脑中受到的抑制最大且显著，在肝脏中受到的抑制最小且不显著。镁ATP酶在脑中受到的抑制最大且显著（P小于0.01），在肾中受到的抑制最小且不显著。所研究组织中总ATP酶、钠钾ATP酶和镁ATP酶的相对抑制程度为脑大于鳃大于肾大于肝脏。在该浓度（1/25部分）下，酶活性恢复到正常范围。