Bring Penny, Partovi Nilufar, Ford Jo-Ann E, Yoshida Eric M
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Pharmacotherapy. 2008 Mar;28(3):331-42. doi: 10.1592/phco.28.3.331.
Iron overload disorders involve excess accumulation of iron in body tissues as a result of hereditary and nonhereditary diseases. If left untreated, tissue iron deposition can result in organ damage. Treatment options such as phlebotomy, chelating agents, and erythrocytapheresis can prevent complications and target organ damage. Although phlebotomy is the gold standard for iron overload treatment in the setting of hereditary hemochromatosis, this procedure is usually not feasible for other iron overload conditions, especially those associated with anemia. With the introduction of newer, oral chelating agents, more options are available for patients refractory to or intolerant of parenteral chelating agents.
铁过载疾病是指由于遗传性和非遗传性疾病导致人体组织中铁过量蓄积。如果不进行治疗，组织铁沉积会导致器官损伤。诸如放血、螯合剂和红细胞单采术等治疗方法可以预防并发症并防止靶器官损伤。虽然放血是遗传性血色素沉着症中铁过载治疗的金标准，但该方法通常不适用于其他铁过载情况，尤其是那些与贫血相关的情况。随着新型口服螯合剂的出现，对于那些对肠外螯合剂难治或不耐受的患者有了更多选择。
