Hendry P O, Balfour A, Potter M A, Mander B J, Bartolo D C C, Anderson D N, Fearon K C H
Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh, Edinburgh, UK.
Colorectal Dis. 2008 Nov;10(9):907-10. doi: 10.1111/j.1463-1318.2008.01499.x. Epub 2008 Feb 21.
Preoperative conditioning with oral fluid and carbohydrate (CHO) loading allows the patient to undergo surgery in the fed state and is associated with reduced postoperative insulin resistance. Further benefit may accrue from oral nutritional supplements (ONS) to counteract the fasting associated with mechanical bowel preparation (MBP). In this study we assess the ability to prescribe, dispense and have patients comply with a protocol combining preoperative ONS and CHO/fluid loading during MBP.
One hundred and forty-seven patients undergoing elective left colonic or rectal resection were recruited to an Enhanced Recovery after Surgery (ERAS) programme. All patients were prescribed MBP (2 sachets Picolax). On the daytime prior to surgery, eligible patients were prescribed 2 x 200 ml of ONS (Fortijuice, Nutricia) and in the evening 800 ml oral CHO/fluid loading (Preop(R), Nutricia,). Patients were prescribed a further 400 ml of oral/CHO/fluid on the morning of surgery 2 h prior to induction of anaesthesia. Protocol compliance was audited prospectively.
One hundred and forty-seven patients received MBP. Twenty-three patients were ineligible for oral CHO/fluid loading [diabetes (n = 22), allergy to lemon flavoured drinks (n = 1)]. Fourteen patients did not receive the preoperative CHO drinks due to failure to prescribe (n = 8) or dispense (n = 6). One hundred and ten patients were dispensed the combined ONS and CHO/fluid loading regimen, compliance rates were 83% with ONS, 80% with CHO/fluid loading and 74% with both.
Approximately 74% of patients undergoing MBP can comply with preoperative conditioning with ONS and CHO/fluid loading. Prescription and dispensing requires close attention to detail.
术前口服液体和碳水化合物(CHO)负荷预处理可使患者在进食状态下接受手术,并与降低术后胰岛素抵抗相关。口服营养补充剂(ONS)可能会带来进一步的益处,以抵消与机械性肠道准备(MBP)相关的禁食。在本研究中,我们评估了开具、分发ONS以及让患者遵守在MBP期间联合术前ONS和CHO/液体负荷方案的能力。
147例接受择期左半结肠或直肠切除术的患者被纳入术后加速康复(ERAS)计划。所有患者均接受MBP(2袋聚乙二醇电解质散)。在手术前一天白天,符合条件的患者被开具2×200ml的ONS(能全力,纽迪希亚),晚上给予800ml口服CHO/液体负荷(术前饮,纽迪希亚)。在手术当天上午麻醉诱导前2小时,给患者再开具400ml口服/CHO/液体。对方案依从性进行前瞻性审核。
147例患者接受了MBP。23例患者不符合口服CHO/液体负荷的条件[糖尿病(n = 22),对柠檬味饮料过敏(n = 1)]。14例患者因未开具(n = 8)或未分发(n = 6)而未接受术前CHO饮料。110例患者接受了ONS和CHO/液体负荷联合方案,ONS的依从率为83%,CHO/液体负荷的依从率为80%,两者均依从的率为74%。
约74%接受MBP的患者能够遵守术前ONS和CHO/液体负荷预处理。开具处方和分发需要密切关注细节。