Prevalence and incidence of Parkinson's disease in The Faroe Islands.
作者信息
Wermuth L, Bech S, Petersen M Skaalum, Joensen P, Weihe P, Grandjean P
机构信息
Department of Neurology, Odense University Hospital, Odense, Denmark.
出版信息
Acta Neurol Scand. 2008 Aug;118(2):126-31. doi: 10.1111/j.1600-0404.2007.00991.x. Epub 2008 Feb 19.
OBJECTIVE
A study in The Faroe Islands in 1995 suggested a high prevalence of idiopathic Parkinson's disease (IPD) and total parkinsonism of 187.6 and 233.4 per 100,000 inhabitants respectively.
METHODS
Detailed case-finding methods 10 years later were used and a neurologist has verified the diagnosis.
RESULTS
The crude prevalence of IPD and total parkinsonism was 206.7 per 100,000 and 227.4 per 100,000 respectively. The age-adjusted prevalence is twice as high as data from Norway and Denmark. Age at initiation of treatment and the fatality rate did not explain the increased prevalence. During 1995-2005, the average annual incidence was 21.1 per 100,000 persons for Parkinson's disease, and 22.9 per 100,000 persons, if including atypical parkinsonism.
CONCLUSION
The high prevalence was verified and linked to a high incidence. The cause of the high prevalence is unknown, but neurotoxic contaminants in traditional food may play a role in the pathogenesis in this population, perhaps jointly with genetic predisposition.
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