Tandberg E, Larsen J P, Nessler E G, Riise T, Aarli J A
Department of Neurology, Central Hospital of Rogaland, Stavanger, Norway.
Mov Disord. 1995 Sep;10(5):541-9. doi: 10.1002/mds.870100503.
The objective of this investigation was to clarify the epidemiology of idiopathic Parkinson's disease (PD) in the county of Rogaland, Norway. Total case ascertainment and a high diagnostic accuracy were attempted through a detailed community study and the use of a new clinical diagnostic classification. The study population comprised 220,858 inhabitants, and a total of nearly 400 patients was interviewed and examined by a neurologist. On prevalence day, January 1, 1993, 245 patients were included in the study. The diagnostic classification revealed 135 patients with clinically definite, 74 with probable, and 36 with possible PD. The crude prevalence rate was shown to be 110.9 per 100,000 inhabitants. The total age-adjusted prevalence was calculated to be 102.4 per 100,000 and to 120.9 per 100,000 men and 89.8 per 100,000 women. Among the 245 patients, 28 patients had a tremor-dominant disease, 50 patients an akinetic-dominant disease, and 167 patients a mixed clinical pattern of PD. Age-adjusted prevalence figures were slightly higher for rural compared to urban areas. About 50% of the PD patients were in need of public help, 15% had complaints about pain related to their parkinsonism, and after approximately 6 years of levodopa treatment, 20% were suffering from clinical fluctuations. The study showed that 40% of the patients had some degree of thought disorder. The prevalence figures for PD in this study are slightly lower than those reported from most previous prevalence studies with a comparable study design for case finding. This may be due to a careful diagnostic evaluation with the use of specified diagnostic criteria, excluding patients with other parkinsonian syndromes.
本调查的目的是阐明挪威罗加兰郡特发性帕金森病（PD）的流行病学情况。通过详细的社区研究和使用新的临床诊断分类法，试图实现病例的全面确诊和高诊断准确性。研究人群包括220,858名居民，共有近400名患者接受了神经科医生的访谈和检查。在1993年1月1日患病率调查日，245名患者被纳入研究。诊断分类显示，135例患者临床确诊为PD，74例可能为PD，36例可能患有PD。粗患病率为每10万居民110.9例。经年龄调整后的总患病率计算为每10万居民102.4例，男性为每10万居民120.9例，女性为每10万居民89.8例。在这245名患者中，28例以震颤为主，50例以运动不能为主，167例为PD的混合临床模式。与城市地区相比，农村地区经年龄调整后的患病率略高。约50%的PD患者需要公共帮助，15%的患者有与帕金森病相关的疼痛主诉，在接受左旋多巴治疗约6年后，20%的患者出现临床波动。研究表明，40%的患者有一定程度的思维障碍。本研究中PD的患病率略低于以往大多数采用类似病例发现研究设计的患病率研究报告的结果。这可能是由于使用特定诊断标准进行了仔细的诊断评估，排除了患有其他帕金森综合征的患者。
