毛细胞白血病中PRAME的表达
PRAME expression in hairy cell leukemia.
作者信息
Arons Evgeny, Suntum Tara, Margulies Inger, Yuan Constance, Stetler-Stevenson Maryalice, Kreitman Robert J
机构信息
Laboratories of Molecular Biology and Clinical Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, United States.
出版信息
Leuk Res. 2008 Sep;32(9):1400-6. doi: 10.1016/j.leukres.2007.12.010. Epub 2008 Mar 4.
PRAME has been proposed as a useful marker for solid tumors and acute B-cell malignancies. Several studies demonstrate expression in CLL. To further examine its B-cell tumor distribution, we studied PRAME in both CLL and hairy cell leukemia (HCL). While by conventional PCR only 8% of 37 HCL and 27% of 22 CLL patients were positive, nearly all patients and normal donors expressed PRAME by real-time quantitative (TaqMan) PCR. We conclude that HCL and CLL differ in PRAME overexpression, and that basal normal expression of PRAME may limit its usefulness for following patients with minimal residual CLL or HCL.
PRAME已被提议作为实体瘤和急性B细胞恶性肿瘤的一种有用标志物。多项研究表明其在慢性淋巴细胞白血病（CLL）中表达。为进一步研究其在B细胞肿瘤中的分布，我们对CLL和毛细胞白血病（HCL）中的PRAME进行了研究。通过传统PCR，37例HCL患者中只有8%呈阳性，22例CLL患者中27%呈阳性，而几乎所有患者及正常供者通过实时定量（TaqMan）PCR均表达PRAME。我们得出结论，HCL和CLL在PRAME过表达方面存在差异，且PRAME的基础正常表达可能会限制其在监测微小残留CLL或HCL患者中的作用。
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