de Groot Sonja, Dallmeijer Annet J, Post Marcel W, Angenot Edmond L, van den Berg-Emons Rita J, van der Woude Luc H
Rehabilitation Center Amsterdam, Amsterdam, The Netherlands.
Arch Phys Med Rehabil. 2008 Mar;89(3):531-7. doi: 10.1016/j.apmr.2007.11.023.
To investigate the course of lipid profiles during and 1 year after inpatient rehabilitation of persons with spinal cord injury, and to determine which personal, lesion, and lifestyle characteristics influence the changes in lipid profiles over time and among subjects.
Multilevel regression analysis of measurement points during and after rehabilitation.
Eight rehabilitation centers in The Netherlands.
People with complete and incomplete paraplegia and tetraplegia (N=180).
Not applicable.
Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and the TC/HDL ratio.
We found a significant decrease in TG and TC/HDL during inpatient rehabilitation and a significant increase in HDL during and after inpatient rehabilitation. TC and LDL, however, showed unfavorable increases after clinical discharge. The changes in HDL and LDL over time differed between lesion groups. An increase in the body mass index (BMI) led to an unfavorable change in all lipid profiles. Older participants showed higher TC, LDL, and HDL concentrations. Women and participants who consumed some alcohol, or who were more active 1 year after discharge, had more favorable HDL levels.
Lipid profiles improved during inpatient rehabilitation but deteriorated somewhat after clinical discharge. Controlling one's BMI seems important in diminishing the risk for unfavorable lipid profiles.
研究脊髓损伤患者住院康复期间及康复后1年内血脂水平的变化过程，并确定哪些个人、损伤及生活方式特征会影响血脂水平随时间及个体的变化。
对康复期间及康复后的测量点进行多水平回归分析。
荷兰的8个康复中心。
完全性和不完全性截瘫及四肢瘫患者（N = 180）。
不适用。
总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（TG）以及TC/HDL比值。
我们发现住院康复期间TG和TC/HDL显著降低，住院康复期间及康复后HDL显著升高。然而，临床出院后TC和LDL出现了不利的升高。不同损伤组HDL和LDL随时间的变化有所不同。体重指数（BMI）升高会导致所有血脂指标出现不利变化。年龄较大的参与者TC、LDL和HDL浓度较高。女性以及出院1年后饮酒或活动较多的参与者HDL水平更有利。
住院康复期间血脂水平有所改善，但临床出院后有所恶化。控制BMI对于降低不利血脂水平的风险似乎很重要。
