Sabour Hadis, Norouzi Javidan Abbas, Latifi Sahar, Hadian Mohammad Reza, Emami Razavi Seyed-Hassan, Shidfar Farzad, Vafa Mohammad Reza, Aghaei Meybodi Hamidreza
Brain and Spinal Injury Research Center (BASIR), Tehran University of Medical Sciences, P.O. Box 6114185, Tehran, Iran.
Nutrition Department, Iran University of Medical Sciences, Tehran, Iran.
J Osteoporos. 2014;2014:695014. doi: 10.1155/2014/695014. Epub 2014 Aug 21.
Purpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI. Methods. Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age. Results. We found a positive correlation between HDL and femoral neck BMD (P: 0.004, r = 0.33). HDL was negatively correlated with osteocalcin (P: 0.017, r = -0.31) which was not in consistency with its relationship with BMD. TC and LDL were not related to CTX, BALP and BMD. Conclusion. This study does not support a strong association between serum lipids and BMD in subjects with SCI. Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation.
目的。此前已对血清脂质与骨密度（BMD）之间的关联进行了研究，但截至目前，脊髓损伤（SCI）患者中的这些关系尚未得到描述。我们试图评估男性SCI患者血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）与骨密度之间的相关性。方法。采用双能X线吸收法（DXA）评估股骨颈、大转子、转子间区域和腰椎的骨密度。采集血样以测量血清脂质和骨生物标志物，包括骨钙素、交联I型胶原（CTX）和骨碱性磷酸酶（BALP）。在对体重和年龄进行校正后，采用偏相关分析来评估上述测量值之间的关系。结果。我们发现HDL与股骨颈骨密度呈正相关（P：0.004，r = 0.33）。HDL与骨钙素呈负相关（P：0.017，r = -0.31），这与其与骨密度的关系不一致。TC和LDL与CTX、BALP和骨密度无关。结论。本研究不支持SCI患者血清脂质与骨密度之间存在强关联。此外，HDL与骨密度之间的正相关似乎并非通过增加骨形成介导。
