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钾离子通道蛋白基因（kdr）：单个突变能产生完整的抗杀虫剂表型吗？

kdr: can a single mutation produce an entire insecticide resistance phenotype?

作者信息

Brooke Basil D

机构信息

Vector Control Reference Unit, National Institute for Communicable Diseases, NHLS, Sandringham, South Africa.

出版信息

Trans R Soc Trop Med Hyg. 2008 Jun;102(6):524-5. doi: 10.1016/j.trstmh.2008.01.001. Epub 2008 Mar 4.

DOI:10.1016/j.trstmh.2008.01.001
PMID:18295809
Abstract

Knockdown resistance (kdr) is closely associated with DDT and pyrethroid resistance in the major malaria vector Anopheles gambiae and is considered to be causative of the resistance phenotype. The same association does not apply to Sudanese populations of the closely related malaria vector A. arabiensis. Speculation on this discrepancy and on the incidence of multiple insecticide resistance and cross-resistance has implications for the manner in which entomological surveys are conducted in the field as well as on the array of technologies employed to produce usable data.

摘要

击倒抗性（kdr）与主要疟疾媒介冈比亚按蚊对滴滴涕和拟除虫菊酯的抗性密切相关，被认为是抗性表型的成因。这种关联在密切相关的疟疾媒介阿拉伯按蚊的苏丹种群中并不适用。对这种差异以及多种杀虫剂抗性和交叉抗性发生率的推测，对实地进行昆虫学调查的方式以及用于生成可用数据的一系列技术都有影响。

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