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喀麦隆冈比亚按蚊（疟疾传播媒介）基因敲除突变的首次报告。

First report of knockdown mutations in the malaria vector Anopheles gambiae from Cameroon.

作者信息

Etang Josiane, Fondjo Etienne, Chandre Fabrice, Morlais Isabelle, Brengues Cecile, Nwane Philippe, Chouaibou Mouhamadou, Ndjemai Hamadou, Simard Frédéric

机构信息

Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale, Yaounde, Cameroon.

出版信息

Am J Trop Med Hyg. 2006 May;74(5):795-7.

PMID:16687682
Abstract

We report the first finding of the knockdown Leu-Phe and Leu-Ser mutations associated with resistance to pyrethroids and DDT insecticides in the malaria mosquito Anopheles gambiae from Cameroon. The Leu-Phe mutation was found in both the M and S molecular forms of An. gambiae. Importantly, two specimens of the S molecular form were found to carry both mutations in a heterozygous state.

摘要

我们报告了在喀麦隆冈比亚按蚊中首次发现与对拟除虫菊酯和滴滴涕杀虫剂产生抗性相关的亮氨酸-苯丙氨酸（Leu-Phe）和亮氨酸-丝氨酸（Leu-Ser）突变。在冈比亚按蚊的M和S分子型中均发现了Leu-Phe突变。重要的是，发现S分子型的两个样本以杂合状态携带这两种突变。

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