Park Jung Han Yoon
Hallym University, Department of Food Sciences and Nutrition, Chuncheon, Korea.
Asia Pac J Clin Nutr. 2008;17 Suppl 1:257-60.
Large bowel cancer is one of the leading causes of deaths from cancer in Western countries, and the incidence of colorectal cancer is increasing with the steady increase in life expectancy. Modification of diet and lifestyle provide measures of reducing the risk of developing colon cancer. Evidence suggests that the components of the insulin-like growth factor (IGF) system may be appropriate targets for cancer prevention and therapy. A positive correlation was found between dietary and lifestyle, plasma IGF-I, and colon cancer incidence rates. Diet, nutrition, and other lifestyle features affect the expression and production of IGF-1 and other members of the IGF family. The purpose of this review is to examine current evidence obtained from our recent studies and others that investigated the role of dietary components in the regulation of the IGF system and colon cancer cell growth.
在西方国家，大肠癌是癌症致死的主要原因之一，并且随着预期寿命的稳步增长，结直肠癌的发病率也在上升。饮食和生活方式的改变提供了降低患结肠癌风险的措施。有证据表明，胰岛素样生长因子（IGF）系统的组成部分可能是癌症预防和治疗的合适靶点。在饮食与生活方式、血浆IGF-I和结肠癌发病率之间发现了正相关。饮食、营养和其他生活方式特征会影响IGF-1及IGF家族其他成员的表达和产生。本综述的目的是研究从我们最近的研究以及其他调查饮食成分在调节IGF系统和结肠癌细胞生长中作用的研究中获得的现有证据。
