Clinkingbeard C, Lawrence D, Shenker Y
Medical Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705.
Am J Hypertens. 1991 May;4(5 Pt 1):456-9. doi: 10.1093/ajh/4.5.456.
To further assess the mechanism of atrial natriuretic hormone (ANH) induced suppression of aldosterone, we infused 0.5 pmol/kg/min Ser-Tyr28 human ANH over 2 h under three dietary conditions: low salt (LS), low potassium (LK), and high potassium (HK). The diets were consumed for 3 days before each study day. After 3 days of LK diet, blood pressure was slightly higher than under the other conditions. Serum potassium on LK was significantly lower than on HK (3.8 +/- 0.1 v 4.3 +/- 0.2). The ANH infusion did not cause any changes in blood pressure or urinary sodium and potassium excretion. Urine volume increased with ANH infusion under all diet conditions. Plasma renin activity and plasma angiotensin II levels were significantly lower on LK than on LS or HK, probably reflecting sodium retention. Increase in plasma ANH levels of about 75% (well within normal range) suppressed all hormonal parameters on LS and HK diets, but had no significant effect on LK diet. The pattern of aldosterone changes closely followed the changes in the renin-angiotensin system. We conclude that under various physiologic conditions ANH suppresses aldosterone predominantly through suppression of renin.
为了进一步评估心房利钠肽（ANH）诱导醛固酮抑制的机制，我们在三种饮食条件下，即低盐（LS）、低钾（LK）和高钾（HK）饮食，以0.5 pmol/kg/分钟的速率静脉输注Ser-Tyr28人ANH 2小时。在每个研究日之前，每种饮食均持续食用3天。食用3天LK饮食后，血压略高于其他条件下的血压。LK饮食组的血清钾显著低于HK饮食组（3.8±0.1对4.3±0.2）。输注ANH未引起血压、尿钠和尿钾排泄的任何变化。在所有饮食条件下，输注ANH后尿量均增加。LK饮食组的血浆肾素活性和血浆血管紧张素II水平显著低于LS或HK饮食组，这可能反映了钠潴留情况。血浆ANH水平升高约75%（仍在正常范围内）可抑制LS和HK饮食组的所有激素参数，但对LK饮食组无显著影响。醛固酮变化模式与肾素-血管紧张素系统的变化密切相关。我们得出结论，在各种生理条件下，ANH主要通过抑制肾素来抑制醛固酮。
