Rana Shadna A, Parker Linda A
Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.
Behav Brain Res. 2008 Jun 3;189(2):284-97. doi: 10.1016/j.bbr.2008.01.005. Epub 2008 Jan 19.
When rats are intraorally exposed to saccharin solution that has previously been paired with lithium chloride (LiCl), they display Pavlovian conditioned disgust reactions. When exposed to LiCl-paired saccharin solution by bottle, they display suppressed instrumental approach to the bottle resulting in suppressed consumption. The present experiments demonstrated that while neither neurotoxin-induced lesions of the basolateral amygdala (BLA) nor the central nucleus of the amygdala (CeA) attenuated the display of Pavlovian conditioned disgust reactions, lesions of the BLA (but not the CeA) attenuated instrumental conditioned avoidance of the taste. The results are discussed in light of current models of the role of the amygdala in aversive learning.
当大鼠经口接触先前已与氯化锂（LiCl）配对的糖精溶液时，它们会表现出巴甫洛夫条件性厌恶反应。当通过瓶子接触与LiCl配对的糖精溶液时，它们对瓶子的工具性接近行为受到抑制，导致摄入量减少。本实验表明，虽然基底外侧杏仁核（BLA）或杏仁核中央核（CeA）的神经毒素诱导损伤均未减弱巴甫洛夫条件性厌恶反应的表现，但BLA（而非CeA）的损伤减弱了对该味道的工具性条件性回避。根据当前关于杏仁核在厌恶学习中作用的模型对结果进行了讨论。
