Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Ontario, Canada.
Physiol Behav. 2012 Feb 1;105(3):856-60. doi: 10.1016/j.physbeh.2011.10.017. Epub 2011 Oct 25.
Rats selectively display conditioned gaping reactions when re-exposed to flavours previously paired with nausea-inducing treatments and drugs that reduce nausea also reduce these reactions, suggesting that they represent a model of nausea-induced behavior in rats. However, these reactions rely upon learning, they are not unconditional malaise-induced reactions. Here we compared the effectiveness of the anti-nausea drug, ondansetron (OND) to interfere with the establishment of conditioned gaping reactions and the unconditional malaise-induced reaction of lying on belly (LOB). Pretreatment with OND significantly reduced both LiCl-induced LOB and conditioned gaping reactions, without modifying conditioned taste avoidance. The frequency of gaping and duration of LOB were highly correlated. These results provide additional support for the validity of the conditioned gaping model as a rodent model of nausea-induced behavior.
当大鼠再次暴露于先前与恶心诱发治疗和减少恶心的药物配对的味道时，它们会选择性地表现出条件性张口反应，这表明它们代表了大鼠恶心诱导行为的模型。然而，这些反应依赖于学习，它们不是无条件的不适诱导反应。在这里，我们比较了抗恶心药物昂丹司琼（OND）的有效性，以干扰条件性张口反应和腹部躺着的无条件不适反应（LOB）的建立。OND 的预处理显著减少了 LiCl 诱导的 LOB 和条件性张口反应，而不改变条件性味觉回避。张口的频率和 LOB 的持续时间高度相关。这些结果为条件性张口模型作为一种诱导恶心的啮齿动物行为模型的有效性提供了额外的支持。
